Spanish Biotech Platform
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Fundación Pública Andaluza para la investigación Biosanitaria de Andalucía oriental (FIBAO)
Predictive model for assessing refractoriness in patients with temporal
A research group of the Andalusia Public Health System has developed a
predictive model for assessing refractoriness in patients with temporal lobe epilepsy.
Temporal lobe epilepsy (TLE) is among the most common type
of epilepsy in humans (15-20%). Some 20-40% of TLE cases are
refractory, ie where the epileptic seizures have persisted in the
face of drug therapy strategies. For such patients, nonpharmacological
treatments options exist, such as surgery,
which has high rates of success.
Surgery is also the only solution in cases of progressive
refractory epilepsy, in order to halt their progress. The problem
is that most patients do not opt to undergo surgery within the
first 20 years of having the condition. As a result, they are
exposed to the adverse effects of long-term use of complex
combination therapies, resulting in secondary cognitive and
systemic impairments and a lower quality of life.
The research group has developed a diagnostic model for
predicting TLE refractoriness, based on a simple algorithm
involving clinical features and laboratory tests. It can be applied
from the first moments of care.
The validation of the research involved a cohort of 163 patients
(83 refractory TLE cases and 80 non-refractory cases).
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